Endocrine Abstracts

Little is known about the molecules that contribute to tumor growth in epithelial ovarian cancer (EOC) that remain the most lethal gynecological neoplasm. Glucocorticoid-Induced Leucine Zipper (GILZ), a leucine zipper protein of 17 kDa, is frequently detected in epithelial tissues with a hormonal background. We detected GILZ in EOC1 and we further demonstrated that this factor which expression is enhanced by estradiol (E2), activates tumor cell proliferat...